LH/hCG receptor ELISA: Diagnostic tests for fertility treatment (IVF) and early detection of pregnancy disorders
Origin Biomarkers has developed three novel diagnostics. These tests measure the blood concentration of the soluble (circulating) form of LHCGR and its complex with hormones LH and hCG by ELISA.
Test 1: sLHCGR alone
Test 2: LH-sLHCGR (Hormone-receptor complex)
Test 3: hCG-sLHCGR (Hormone-receptor complex)
Under Development & Validation: TSH-LHCGR
Background of the tests
Under the direction of gonadotropin releasing hormone (GNRH) derived from the hypothalamus (brain), the pituitary secretes luteinizing hormone (LH) which stimulates the ovary and testis leading to the production of estrogen and androgens (testosterone) in women and men respectively. However, in a feed-back mechanism, the hypothalamic pituitary gonadal (HPG) axis is negatively regulated by gonadal steroids. LH is a homologue of pregnancy hormone human chorionic gonadotropin (hCG). In addition to placenta, hCG is also secreted from pituitary in women at menopause.
LH and hCG both bind to a common receptor termed LHCGR which is expressed in numerous tissues including adrenal glands, brain, skin, retina etc as well as the reproductive organs. The non-gonadal expression of the LHCGR has been shown to be necessary for local steroid production. Diabetes, thyroid diseases, renal dysfunctions, advanced age, inflammatory conditions, stress etc support the release of soluble LHCGR from the inflamed tissues into the circulation.
One in eight women & men suffer infertility
Secretion of sLHCGR from tissues followed by detection of sLHCGR in blood and follicular fluid.
Based on unique biomarkers for EARLY detection of preeclampsia and other pregnancy diseases/infertility
IVF / Fertility Treatments
Oocyte yield, Early Pregnancy loss, Premature birth, Low/high birth weight Reduce multiple births without compromising success rate.
Premature Birth, Miscarriage, Down’s Syndrome, Preeclampsia
Testing for early development of cognitive failures and Alzheimer’s